2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-17616
    Ingenol disoxate
    Ingenol disoxate (LEO 43204) is a drug metabolite, that exhibits potential in ameliorating actinic keratosis.
    Ingenol disoxate
  • HY-136576
    RP101075
    RP101075, an active metabolite of Ozanimod, is a potent, orally active S1PR (sphingosine-1-phosphate receptor 1) agonist, with an EC50 of 0.27 nM. RP101075 displays >100-fold selectivity over S1PR5 (EC50=5.9 nM) and >10000-fold over S1PR 2, 3, and 4. RP101075 displays superior cardiovascular safety profile.
    RP101075
  • HY-135390
    Hydroxy desmethyl Bosentan
    Hydroxy desmethyl Bosentan (Ro 64-105) is a Bosentan metabolism produced by the cytochrome P450 enzymes CYP2C9 and CYP3A4 in the liver. Bosentan is a competitive and dual antagonist of endothelin-1 (ET) for the ETA and ETB receptors with Ki of 4.7 nM and 95 nM in human SMC, respectively. Bosentan can be used in treatment of pulmonary arterial hypertension.
    Hydroxy desmethyl Bosentan
  • HY-B0113S2
    Omeprazole metabolite Omeprazole sulfone (methoxy-d3)
    		≥99.0%
    Omeprazole metabolite Omeprazole sulfone (methoxy-d3) is the deuterium labeled Omeprazole metabolite Omeprazole sulfone. Omeprazole sulfone is a metabolite of Omeprazole, which is a proton pump inhibitor.
    Omeprazole metabolite Omeprazole sulfone (methoxy-d<sub>3</sub>)
  • HY-12772S1
    (2R,4S)-Hydroxy Itraconazole-d8
    (2R,4S)-Hydroxy Itraconazole-d8 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].
    (2R,4S)-Hydroxy Itraconazole-d<sub>8</sub>
  • HY-10873S
    N-Desethyl Sunitinib-d5
    N-Desethyl Sunitinib-d5 is the deuterium labeled N-Desethyl Sunitinib. N-Desethyl Sunitinib (SU-12662) is a metabolite of sunitinib. Sunitinib is a potent, ATP-competitive VEGFR, PDGFRβ and KIT inhibitor with Ki values of 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFRβ and KIT, respectively[1].
    N-Desethyl Sunitinib-d<sub>5</sub>
  • HY-18719ES
    Endoxifen-d5
    Endoxifen-d5 is the deuterium labeled Endoxifen. Endoxifen is a key active metabolite of tamoxifen (TAM) with higher affinity and specificity to estrogen receptor that also inhibits aromatase activity. Endoxifen has the potential for breast cancer study[1][2].
    Endoxifen-d<sub>5</sub>
  • HY-132617S
    Carboxy Gliclazide-d4
    		Modulator
    Carboxy Gliclazide-d4 is the deuterium labeled Carboxy Gliclazide[1].
    Carboxy Gliclazide-d<sub>4</sub>
  • HY-108251S
    Methotrexate metabolite-d3
    Methotrexate metabolite-d3 is the deuterium labeled Methotrexate metabolite. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent[1].
    Methotrexate metabolite-d<sub>3</sub>
  • HY-100662S
    Didesethyl chloroquine-d4
    Didesethyl chloroquine-d4 is the deuterium labeled Didesethyl chloroquine. Didesethyl chloroquine (Bisdesethylchloroquine) is a major metabolite of the antimalarial agent Chloroquine. Didesethyl chloroquine is a potent myocardial depressant[1][2].
    Didesethyl chloroquine-d<sub>4</sub>
  • HY-12772S2
    (2R,4S)-Hydroxy Itraconazole-d5
    (2R,4S)-Hydroxy Itraconazole-d5 is the deuterium labeled (2R,4S)-Hydroxy Itraconazole[1].
    (2R,4S)-Hydroxy Itraconazole-d<sub>5</sub>
  • HY-153408
    4-Hydroxylidocaine
    4-Hydroxylidocaine is a Lidocaine (HY-B0185) metabolite.
    4-Hydroxylidocaine
  • HY-B1786R
    Sulindac sulfide (Standard)
    Sulindac sulfide (Standard) is the analytical standard of Sulindac sulfide. This product is intended for research and analytical applications. Sulindac sulfide is a noncompetitive γ-secretase inhibitor, with an IC50 of 20.2 μM for γ42-secretase activity.
    Sulindac sulfide (Standard)
  • HY-135586
    Raloxifene N-Oxide
    Raloxifene N-Oxide is a Raloxifene oxidative degradation product.
    Raloxifene N-Oxide
  • HY-20390S
    Lapatinib impurity 18-d4
    Lapatinib impurity 18-d4 is deuterium labeled 3-Chloro-4-((3-fluorobenzyl)oxy)aniline.
    Lapatinib impurity 18-d<sub>4</sub>
  • HY-133774
    Trityl olmesartan medoxomil impurity III
    Trityl olmesartan medoxomil impurity III is an impurity of Trityl olmesartan medoxomil. Trityl olmesartan medoxomil is an intermediate of Olmesartan medoxomil.
    Trityl olmesartan medoxomil impurity III
  • HY-135151
    Difluoro atorvastatin
    Difluoro atorvastatin (Fluoroatorvastatin) is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively.
    Difluoro atorvastatin
  • HY-W011235S
    Norfluoxetine-d5 hydrochloride
    		99.57%
    Norfluoxetine-d5 (hydrochloride) is deuterium labeled 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride.
    Norfluoxetine-d<sub>5</sub> hydrochloride
  • HY-12388AR
    N-Desmethyl clomipramine hydrochloride (Standard)
    N-Desmethyl Clomipramine (hydrochloride) (Standard) is the analytical standard of N-Desmethyl Clomipramine (hydrochloride). This product is intended for research and analytical applications. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant.
    N-Desmethyl clomipramine hydrochloride (Standard)
  • HY-B1986S
    p,p'-DDE-d8
    p,p'-DDE-d8 is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].
    p,p'-DDE-d<sub>8</sub>
Cat. No. Product Name / Synonyms Application Reactivity